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Meclizine
Meclizine (INN,〔(Guidelines on the Use of INNs for Pharmaceutical Substances (1997). ) Accessed November, 2013 "Guidance on INN." WHO.〕 or meclozine) is an antihistamine considered to be an antiemetic. It is sold under the brand names Bonine, Bonamine, Antivert, Postafen, Sea Legs, and Dramamine (Less Drowsy Formulation). Emesafene is a combination of meclizine (1/3) and pyridoxine (2/3). In Canada, Antivert Tab (which is no longer available) was a combination of meclizine and nicotinic acid.〔DrugBank. (Drugbank: Drug card for Meclizine ) David Wishard: University of Alberta, Canada. Accessed November 7, 2010.〕
==Classification==
Meclizine is a first-generation antihistamine of the piperazine class. It is structurally and pharmacologically similar to buclizine, cyclizine, and hydroxyzine, but has a shorter half-life of six hours compared to cyclizine and hydroxyzine with about 20 hours (though half-life should not be confused with duration). It is used as an antivertigo/antiemetic agent, specifically in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness.〔Clinical Pharmacology. (Clinical Pharmacology ), revised November 20, 2009, accessed November 7, 2010.〕 Meclizine is sometimes combined with opioids, especially ones of the open-chain class like methadone, dextropropoxyphene, and dipipanone (originally combined with meclizine's parent drug cyclizine, the brand name of this combination is Diconal).
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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